P11

P11-08. Abstract withdrawn

Serotonin, cytokines, p11, and depression.

F or at least four decades, the field of psychoimmunology has attracted numerous investigators based on diverse hints linking the immune system to emotional behavior. The administration of cytokines for the treatment of various diseases is often associated with depression, which frequently accompanies autoimmune disease. Now, in PNAS, Greengard and colleagues (1) report a specific molecular pat...

P11 expression and PET in bipolar disorders.

BACKGROUND Bipolar disorder (BD) is a common mental disorder, subdivided into BD-I and BD-II. Currently, few biomarkers differentiate BD-I from BD-II. However, it is suggested that peripheral blood mononuclear cell (PBMC) mRNA levels of p11 and positron emission tomography (PET) might be potential biomarkers for BD. METHODS Healthy controls (HCs), BD-I, and BD-II patients in remission (n = 20...

Interferon- Induces p11 Gene and Protein Expression in Human Epithelial Cells through Interferon- -activated Sequences in the p11 Promoter*

The effect of interferon (IFN)on p11 expression was studied in two human epithelial cell lines (BEAS-2B and HeLa). Treatment with IFNresulted in increased steady-state levels of p11 mRNA and protein expression, with a time-dependent and dose-dependent effect. Transient transfection experiments of a reporter gene construct containing 1498 bp of the 5 -flanking region of the p11 promoter demonstr...

P11: Children and Crossing the Road

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